To play B3313, you'll want to get Parallel Launcher. Install it, setup your ROM folder path, then visit this page on romhacking.com. Find the newest patch at the top of the list of patches under "Versions" and click "Play now". Don't use the top-most play button, as this can sometimes load a patch that isn't the newest.
Important: For the best experience, it's recommended to go in blind for at least the first hour of gameplay, if not for an entire first stream. After that, you can use this guide to begin making progress.
If you want to hit the ground running, there are basic starter save files available on the "Gamesaves/Other" page. This can give you a head start when streaming.
Most of the content in this guide was created based on information found on the official B3313 wiki. Thanks to everyone that contributed to the wiki!